Summary

Epi-Guide is the only bioresorbable synthetic matrix with a unique 3-layer technology to provide predictable healing:

• Layer 1: Defect Interface: limited porosity supports a vigorous uptake of fluid blood, facilitates adherence to the tissue surface and prevents fibroblasts from reaching the defect.
• Layer 2: Inner Surface: the inner labyrinth catches fibroblasts and forces them into random pathways while inner chambers enable collateral circulation and unrestricted flow of interstitial fluid through the membrane.
• Layer 3:Gingival Interface:  Numerous voids and interconnected pathways  decelerate fibroblast infiltration, promoting cell attachment

Indications

for adjunctive therapy in periodontal restorative surgery and for Guided Tissue Regeneration (GTR) applications to treat various defects

Histology Confirms the Effective Action of EPI-GUIDE® to yield Predictable Healing

• At 6 weeks: Numerous fronds of connective tissue penetrate the EPI-GUIDE^® barrier and new collagen fibers begin to form within the matrix with no evidence of acute inflammatory response.
• At 13 weeks Connective tissue continues to penetrate the EPI-GUIDE^® bioresorbable barrier showing more defined collagen formation. The barrier remains functional despite initiation of the resorption process.
• At 20 weeks: architecture and structural integrity is maintained as resorption continues
• 6-12 months: EPI-GUIDE^® is completely resorbed