Written by: Dr. Sneha Dhanke | Published on: March 20, 2025
CERASORB® Foam: The Ideal Scaffold for Bone Regeneration and Controlled Antibiotic Release
CERASORB® Foam is a highly advanced, multiporous composite material, consisting of high-quality Type 1 Collagen and pure-phase β-TCP (β -tricalcium phosphate) granules. Since its introduction, it has quickly become a surgeon’s preferred choice in bone regeneration procedures. CERASORB® Foam stands out due to its unique design and innovative approach to regenerative medicine, making it essential for modern bone grafting and healing.
The Ideal Scaffold by Design:
A Closer Look at its 3-dimensional Bone Regeneration Capabilities
CERASORB® Foam is recognized as the “Ideal Scaffold” due to its advanced 3-dimensional collagen matrix structure, which replicates the natural extracellular matrix (ECM) of bone tissue1. This design promotes regeneration by supporting cellular infiltration, vascularization, and tissue integration.
1 Lin, X., Patil, S., Gao, Y. G., & Qian, A. (2020). The bone extracellular matrix in bone formation and regeneration. Frontiers in pharmacology, 11, 757.
1. High-Quality Type-1 Collagen: A Key Factor in Bone Regeneration
Type 1 Collagen plays a crucial role in bone healing by supporting the adhesion of mesenchymal stem cells (MSCs), which are essential for bone regeneration. The process unfolds as follows:
2. Pure-Phase β-TCP in Foam: The Highest Purity in the World
β-TCP is a proven osteoconductive material that supports bone growth.
curasan AG produces the highest purity >99% β-TCP granules, ensuring biocompatibility and osteoconductivity. These granules gradually resorb, facilitating natural bone replacement and providing sustained support during healing.
3. 3-dimensional Structure
The 3-dimensional structure of CERASORB® Foam optimizes osteogenesis. Its open, interconnected pores facilitate cell migration, blood vessel infiltration, and nutrient diffusion creating an ideal environment for bone formation.
4. Biocompatibility and Bioactivity
CERASORB® Foam is well-tolerated by the human body, minimizing inflammatory responses and reducing complications. Its bioactivity and hydrophilicity support new bone formation by interacting seamlessly with the surrounding tissue.
5. Versatility in Application
CERASORB® Foam is suitable for various bone regeneration procedures, including periodontal, maxillofacial, and orthopedic surgeries. It comes in mouldable and flexible forms for both orthopedic and dental applications, offering versatility for surgeons globally.
6. Clinical Validation: Expert Testimonial
“CERASORB® Foam is a true ‘Game Changer’. In socket preservation procedures, CERASORB® Foam is unrivaled and often eliminates the need for an additional augmentation procedure. It has also proven to be highly effective in immediate implantations for bridging the jumping distance.”
~ Prof. Dr. Dr. Frank Palm (Oral and maxillofacial surgeon, Constance, Germany)
This testimonial highlights the proven reliability and effectiveness of CERASORB® Foam in dental and oral surgical applications.
Antibiotic–Loading Capacity:
A Breakthrough in Infection Prevention
1. Why is CERASORB® Foam an Effective Antibiotic Carrier?
Beyond its regenerative properties, CERASORB® Foam is also a highly effective antibiotic carrier, helping prevent infections while supporting bone healing. This is achieved through:
- High absorption capacity, allowing antibiotics to be loaded efficiently.
- Controlled release, ensuring that antibiotic concentrations remain above the Minimum Inhibitory Concentration (MIC) while avoiding cytotoxicity.
- Sustained drug elution, reducing the need for systemic antibiotics and their associated side effects.
- Customized antibiotic selection, enabling surgeons to use patient-specific antibiotic therapies.
2. High Antibiotic Loading and Sustained Release
- CERASORB® Foam has been tested with a wide range of commercially available antibiotics, including Vancomycin, Gentamicin, Tobramycin, and Meropenem.
- It absorbs antibiotics rapidly, ensuring immediate availability at the surgical site.
- The controlled burst release within the first 72 hours achieves antibiotic concentrations above the Minimum Inhibitory Concentration (MIC) but below cytotoxic levels, preventing bacterial growth without compromising cell viability.
3. Superior Release Kinetics Compared to Other Materials
- Studies have shown that CERASORB® Foam has a higher loading and release capacity than other commercially available bone graft materials.
- Unlike traditional materials that release antibiotics too quickly, CERASORB® Foam provides a prolonged and steady elution, with some formulations maintaining antibiotic efficacy for up to 9 days.
4. Clinical Benefits
Case Summary: Antibiotic Validation
A recent study by Hanusrichter et al. (2024) validates the effectiveness of mouldable collagen–β-tricalcium phosphate composite as an antibiotic carrier in revision hip arthroplasty. The study demonstrated excellent short-term infection control in multiple revised hip arthroplasties with severe bone loss and complex microorganism spectrums. The findings suggest that CERASORB® Foam, when used as a local antibiotic carrier, provides a safe and effective alternative for localized antibiotic delivery without causing systemic complications (Antibiotics, 13(6), 510).
- Enables local intraoperative antibiotic application, reducing the need for systemic antibiotics and their associated side effects.
- Supports customized antibiotic selection based on patient-specific infection risks.
- Enhances the overall safety and efficacy of bone defect treatments, particularly in cases of osteomyelitis or revision surgeries.
Conclusion: A New Era in Bone Regeneration and Infection Control
The combination of Type 1 Collagen and β-TCP granules, along with CERASORB® Foam‘s 3-dimensional structure and antibiotic-releasing capability, makes it an effective material for bone regeneration and infection control. Its design enhances cellular infiltration, osteoconduction, and vascularization while ensuring an optimal balance of support, resorption, and drug delivery.
CERASORB® Foam remains a reliable choice for surgeons seeking predictable outcomes in bone regeneration and infection management. By combining antibiotic release with advanced bone healing properties, it sets a high standard in regenerative medicine.